Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
序列
提供的Human CellExp?胰島素R / CD220，人類重組Human CellExp? Insulin R / CD220, Human Recombinant是Biovision品牌中國區域總代理艾美捷科技產品，具體的蛋白序列可查看提供的英文版本產品說明書。
來源宿主
提供的Human CellExp?胰島素R / CD220，人類重組Human CellExp? Insulin R / CD220, Human Recombinant產品來源宿主，查看該產品說明書，或者在線咨詢我們。
溶解建議
Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 μg/ml. Do not vortex. It is recommended to store at -20°C.
