PM20D1 is a recently discovered (2016) enzyme that regulates lipidated amino acid uncouplers of mitochondria. PM20D1 is a secreted and bidirectional enzyme that can generate N-acyl amino acids (NAAs) from amino acids and free fatty acids; it can also hydrolyze NAAs into amino acids and free fatty acids. NAAs can directly bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration. Mouse and human PM20D1 share 71% amino acid identity. Both contain signal peptides and have identical catalytic residues. PM20D1 may be useful in treating obesity and obesity-related disorders. Other studies suggest that PM20D1 is also associated with early childhood wheezing. Ablation of PM20D1 using mouse model reveals physiologic functions of PM20D1 in NAA signaling of metabolism and nociception.
序列
提供的Human CellExp?PM20D1，人類重組Human CellExp? PM20D1, Human Recombinant是Biovision品牌中國區域總代理艾美捷科技產品，具體的蛋白序列可查看提供的英文版本產品說明書。
來源宿主
提供的Human CellExp?PM20D1，人類重組Human CellExp? PM20D1, Human Recombinant產品來源宿主，查看該產品說明書，或者在線咨詢我們。
溶解建議
Centrifuge the vial prior to opening. Reconstitute in sterile water to desired concentration. Do not vortex.
