YWHAZ accession number NP_ 663723 belongs to the 14-3-3 family of proteins which are in charge for checkpoint control， apoptotic & nutrient sensing pathways as well as signal transduction by binding to phosphoserine-containing proteins. The 14-3-3 protein family is found in both plants and mammals， and KCIP-1 protein is 99% identical to the mouse， rat and sheep orthologs. KCIP-1 interacts with IRS1 protein， signifying a role in regulating insulin. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least 7 isoforms， ?， ?， ?， ?， ?， ? and ? that have been identified in mammals. YWHAZ function as an adapter protein involved in the regulation of a large spectrum of both general and specialized signaling pathway. YWHAZ binds to a large number of partners， usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
