Stratifin is part of the 14-3-3 family. The 14-3-3 family of proteins plays an important regulatory function in signal transduction， checkpoint control， apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are 7 isoforms， beta， gamma， epsilon， sigma， zeta， tau and eta that have been identified in mammals. Stratifin is an epithelial cell marker that functions as a tumor suppressor whose expression can be down regulated via methylation. Failure of Stratifin expression results in a defective G2/M phase checkpoint and results in epithelial and non-epithelial tumorigenesis.
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來源宿主
大腸桿菌中重組表達
溶解建議
提供的人Tyr-3/Trp-5單氧酶激活蛋白Sigma（Stratifin）產品為過濾滅菌的無色溶液；其中人Tyr-3/Trp-5單氧酶激活蛋白Sigma（Stratifin）產品溶解于20mM Tris pH 8，50mM NaCl，10%甘油溶液中.
