- 中文名稱
LAMC2 抗體
- 英文名字
- LAMC2 Antibody
- 供應商
- ProSci
- 產品貨號
- PSI-57-399
- 產品報價
- ￥詢價/400ul
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Laminins, a family of extracellular matrix glycoproteins,nare the major noncollagenous constituent of basement membranes.nThey have been implicated in a wide variety of biological processesnincluding cell adhesion, differentiation, migration, signaling,nneurite outgrowth and metastasis. Laminins are composed of 3 nonnidentical chains: laminin alpha, beta and gamma (formerly A, B1,nand B2, respectively) and they form a cruciform structurenconsisting of 3 short arms, each formed by a different chain, and anlong arm composed of all 3 chains. Each laminin chain is anmultidomain protein encoded by a distinct gene. Several isoformsnof each chain have been described. Different alpha, beta and gammanchain isomers combine to give rise to different heterotrimericnlaminin isoforms which are designated by Arabic numerals in thenorder of their discovery, i.e. alpha1beta1gamma1 heterotrimer isnlaminin 1. The biological functions of the different chains andntrimer molecules are largely unknown, but some of the chains havenbeen shown to differ with respect to their tissue distribution,npresumably reflecting diverse functions in vivo. This gene encodesnthe gamma chain isoform laminin, gamma 2. The gamma 2 chain,nformerly thought to be a truncated version of beta chain (B2t), isnhighly homologous to the gamma 1 chain; however, it lacks domainnVI, and domains V, IV and III are shorter. It is expressed innseveral fetal tissues but differently from gamma 1, and isnspecifically localized to epithelial cells in skin, lung andnkidney. The gamma 2 chain together with alpha 3 and beta 3 chainsnconstitute laminin 5 (earlier known as kalinin), which is annintegral part of the anchoring filaments that connect epithelialncells to the underlying basement membrane. The epithelium-specificnexpression of the gamma 2 chain implied its role as an epitheliumnattachment molecule, and mutations in this gene have beennassociated with junctional epidermolysis bullosa, a skin diseasencharacterized by blisters due to disruption of the epidermal-dermalnjunction. Two transcript variants resulting from alternativensplicing of the 3' terminal exon, and encoding different isoformsnof gamma 2 chain, have been described. The two variants arendifferentially expressed in embryonic tissues, however, thenbiological significance of the two forms is not known. Transcriptnvariants utilizing alternative polyA_signal have also been noted innliterature.
- 應用類型
- WB
- 免疫原
- This LAMC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 941-970 amino acids from the Central region of human LAMC2.
- 來源宿主
- 兔
- 反應性
- 小鼠
- 保存建議
- Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- 其他
- ProSci Incorporated于1998年成立于美國加州圣地亞哥市,從事抗體等科研試劑的研發、生產和銷售。產品涵蓋了細胞凋亡、信號轉導、免疫、腫瘤、細胞生物、神經生物、傳染病等領域。ProSci擁有超過30000種單克隆抗體和多克隆抗體。ProSci的抗體大都經免疫親和層析純化,具有高純度、高親和力、特異性強等特點,所有的ProSci抗體都經過了嚴格的驗證測試和質量控制,已保證高質量的產品。此外,ProSci還提供標記二抗,重組蛋白,細胞和組織裂解液,細胞涂片,組織切片,多肽等產品與抗體配套使用。
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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