TNNT3 抗體-TNNT3 Antibody代理/參數/廠家-一抗-艾美捷科技有限公司

PRODUCT CENTER

一抗

產品中心

當前位置：首頁 > 產品中心 > 免疫學產品 > 一抗

背景資料: The binding of Ca(2+) to the trimeric troponin complexninitiates the process of muscle contraction. Increased Ca(2+)nconcentrations produce a conformational change in the troponinncomplex that is transmitted to tropomyosin dimers situated alongnactin filaments. The altered conformation permits increasedninteraction between a myosin head and an actin filament which,nultimately, produces a muscle contraction. The troponin complex hasnprotein subunits C, I, and T. Subunit C binds Ca(2+) and subunit Inbinds to actin and inhibits actin-myosin interaction. Subunit Tnbinds the troponin complex to the tropomyosin complex and is alsonrequired for Ca(2+)-mediated activation of actomyosin ATPasenactivity. There are 3 different troponin T genes that encodentissue-specific isoforms of subunit T for fast skeletal-, slownskeletal-, and cardiac-muscle. This gene encodes fast skeletalntroponin T protein; also known as troponin T type 3. Alternativensplicing results in multiple transcript variants encodingnadditional distinct troponin T type 3 isoforms. A developmentallynregulated switch between fetal/neonatal and adult troponin T type 3nisoforms occurs. Additional splice variants have been described butntheir biological validity has not been established. Mutations innthis gene may cause distal arthrogryposis multiplex congenita typen2B (DA2B).

免疫原: This TNNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the C-terminal region of human TNNT3.

保存建議: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

其他: ProSci Incorporated于1998年成立于美國加州圣地亞哥市,從事抗體等科研試劑的研發、生產和銷售。產品涵蓋了細胞凋亡、信號轉導、免疫、腫瘤、細胞生物、神經生物、傳染病等領域。ProSci擁有超過30000種單克隆抗體和多克隆抗體。ProSci的抗體大都經免疫親和層析純化,具有高純度、高親和力、特異性強等特點,所有的ProSci抗體都經過了嚴格的驗證測試和質量控制,已保證高質量的產品。此外,ProSci還提供標記二抗,重組蛋白,細胞和組織裂解液,細胞涂片,組織切片,多肽等產品與抗體配套使用。