RAN 抗體-RAN Antibody代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: RAN (ras-related nuclear protein) is a small GTP bindingnprotein belonging to the RAS superfamily that is essential for thentranslocation of RNA and proteins through the nuclear pore complex.nThe RAN protein is also involved in control of DNA synthesis andncell cycle progression. Nuclear localization of RAN requires thenpresence of regulator of chromosome condensation 1 (RCC1).nMutations in RAN disrupt DNA synthesis. Because of its manynfunctions, it is likely that RAN interacts with several othernproteins. RAN regulates formation and organization of thenmicrotubule network independently of its role in thennucleus-cytosol exchange of macromolecules. RAN could be a keynsignaling molecule regulating microtubule polymerization duringnmitosis. RCC1 generates a high local concentration of RAN-GTPnaround chromatin which, in turn, induces the local nucleation ofnmicrotubules. RAN is an androgen receptor (AR) coactivator thatnbinds differentially with different lengths of polyglutamine withinnthe androgen receptor. Polyglutamine repeat expansion in the AR isnlinked to Kennedy's disease (X-linked spinal and bulbar muscularnatrophy). RAN coactivation of the AR diminishes with polyglutaminenexpansion within the AR, and this weak coactivation may lead tonpartial androgen insensitivity during the development of Kennedy'sndisease.

免疫原: This RAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 amino acids from the Central region of human RAN.

保存建議: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

其他: ProSci Incorporated于1998年成立于美國加州圣地亞哥市,從事抗體等科研試劑的研發、生產和銷售。產品涵蓋了細胞凋亡、信號轉導、免疫、腫瘤、細胞生物、神經生物、傳染病等領域。ProSci擁有超過30000種單克隆抗體和多克隆抗體。ProSci的抗體大都經免疫親和層析純化,具有高純度、高親和力、特異性強等特點,所有的ProSci抗體都經過了嚴格的驗證測試和質量控制,已保證高質量的產品。此外,ProSci還提供標記二抗,重組蛋白,細胞和組織裂解液,細胞涂片,組織切片,多肽等產品與抗體配套使用。