- 中文名稱
PKD1/PKC μ (phospho Tyr463) 抗體
- 英文名字
- PKD1/PKC μ (phospho Tyr463) Antibody
- 供應商
- ProSci
- 產品貨號
- PSI-80-011
- 產品報價
- ￥詢價/0.1mg
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Serine/threonine-protein kinase that converts transient diacylglycerol n(DAG) signals into prolonged physiological effects downstream of PKC, and is involved in nthe regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and ntrafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation nby mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, nand plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced napoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal ngrowth factor receptor (EGFR) on dual threonine residues, which leads to the nsuppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and nsubsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 nproteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding nto GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the nheterotrimeric G-protein beta/gamma-subunit complex to maintain the structural nintegrity of the Golgi membranes, and is required for protein transport along the nsecretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport nvesicles that are on their way to the plasma membrane. May act by activating the lipid nkinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of nphosphorylated inositol lipids, which induces a sequential production of DAG, nphosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and ngeneration of specific transport carriers to the cell surface. Under oxidative stress, is nphosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK ncomplex and subsequent nuclear translocation and activation of NFKB1. Involved in cell nmigration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment nin newly forming focal adhesion.
- 應用類型
- WB
- 免疫原
- PKD1/PKC μ (phospho Tyr463) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine463 (R-Y-Y (p)-K-E) derived from Human PKD1/PKC μ.
- 來源宿主
- 兔
- 反應性
- 人, 小鼠, 大鼠
- 保存建議
- Store antibody at -20˚C for up to one year.
- 其他
- ProSci Incorporated于1998年成立于美國加州圣地亞哥市,從事抗體等科研試劑的研發、生產和銷售。產品涵蓋了細胞凋亡、信號轉導、免疫、腫瘤、細胞生物、神經生物、傳染病等領域。ProSci擁有超過30000種單克隆抗體和多克隆抗體。ProSci的抗體大都經免疫親和層析純化,具有高純度、高親和力、特異性強等特點,所有的ProSci抗體都經過了嚴格的驗證測試和質量控制,已保證高質量的產品。此外,ProSci還提供標記二抗,重組蛋白,細胞和組織裂解液,細胞涂片,組織切片,多肽等產品與抗體配套使用。
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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