SCF, Recombinant, Human (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)-SCF, Recombinant, Human (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)代理/參數/廠家-細胞分析試劑盒-艾美捷科技有限公司

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中文名稱: SCF, Recombinant, Human (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)

英文名字: SCF, Recombinant, Human (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)

供應商: USBiological

產品貨號: S7973-01A

產品報價: ￥1/10ug

產品說明書: 點擊查看

購買方式: 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

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背景資料

產品描述: Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40kD type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature human SCF consists of a 189aa extracellular domain (ECD), a 23aa transmembrane segment, and a 36aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25kD soluble molecule which is comparable to the only formproduced by Steel-dickie mutant mice. An alternatively spliced isoform of human SCF exists that lacks 28aa that encompass the primary proteolytic recognition site. Within the ECD of the long isoform (corresponding to this recombinant protein), human SCF shares 79%-87% aa sequence identity with canine, feline, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.Source:Recombinant protein corresponding to aa26-189 from human SCF expressed in HEK293.Molecular Weight:~18.5kDEndotoxin: ~1EU/1ug (LAL)Biological Activity:Measured in a cell proliferation assay using TF1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is typically 1-5ng/ml.Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS and BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

產品特點: 針對SCF, Recombinant, Human (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)該產品的特點優勢，歡迎查閱官網提供的產品說明書。

保存建議: 建議收到SCF, Recombinant, Human (Kit Ligand, Mast Cell Growth Factor, MGF, Stem Cell Factor, c-Kit Ligand, KITLG)產品后將其置于-20°C保存。

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