- 中文名稱
熱休克蛋白25/27抗體
- 英文名字
- HSP25/HSP27 Antibody: Dylight 633
- 供應商
- StressMarq
- 產品貨號
- SMC-114D-DY633
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- StressMarq中國區現貨中心已經建立，90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- HSP25 is the mouse homologue of the human HSP27 protein, a member of the small heat shock protein family comprised of a diverse group of proteins from ~15 to >30kDa(1). The basic structure of most sHSPs is a homologous and highly conserved amino acid sequence, with an A-crystallin-domain at the C-terminus and the WD/EPF domain at the less conserved N-terminus. This N-terminus is essential for the development of high molecular oligomers (2, 3). HSP27-oligomers consist of stable dimers formed by as many as 8-40 HSP27 protein monomers (4). The oligomerization status is connected with the chaperone activity: aggregates of large oligomers have high chaperone activity, whereas dimers have no chaperone activity (5). HSP27 is localized to the cytoplasm of unstressed cells but can redistribute to the nucleus in response to stress, where it may function to stabilize DNA and/or the nuclear membrane. It can be rapidly phosphorylated in response to physiological stimuli relevant to the cell type examined. Thus, HSP27 has been suggested to be an important intermediate in second messenger-mediated signaling pathways (6). Other functions include chaperone activity (as mentioned above), thermo-tolerance in vivo, inhibition of apoptosis, and signal transduction. nSpecifically, in vitro, it acts as an ATP-independent chaperone by inhibiting protein aggregation and by stabilizing partially denatured proteins, which ensures refolding of the HSP70 complex. HSP27 is also involved in the apoptotic signaling pathway because it interferes with the activation of cytochrome c/Apaf-1/dATP complex, thereby inhibiting the activation of procaspase-9. It is also hypothesized that HSP27 may serve some role in cross-bridge formation between actin and myosin (7). And finally, HSP27 is also thought to be involved in the process of cell differentiation. The up-regulation of HSP27 correlates with the rate of phosphorylation and with an increase of large oligomers. It is possible that HSP27 may play a crucial role in termination of growth (8). Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at HSP27.com.
- 應用類型
- WB | IHC | ICC/IF | IP | FCM | FACS
- 免疫原
- Hsp27 肽
- 來源宿主
- 小鼠
- 反應性
- 人 | 小鼠 | 大鼠 | 牛 | 狗 | 豚鼠 | 倉鼠 | 綿羊
- 保存建議
- 廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
- 其他
- StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍及全球50多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，StressMarq還提供全新的尖端研究工具，用于開發新的生物項目，包括全球獨一無二的A B晶體蛋白ELISA試劑盒（現在是公認的乳腺癌標志物）；熱休克同源蛋白70（Hsc70）ELISA試劑盒；以及用于神經衰退研究的Tau活性蛋白與A-突觸核蛋白。本公司已將專業技術擴展到抗體、小分子離子通道與載體等更新領域，前者包括當前熱門的核心領域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括當前熱門的核心領域：ENaC、NCC和NKCC2以及主要水通道蛋白載體。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
