MAPKAPK2 is a protein-serine/threonine kinase regulated through direct phosphorylation by p38 MAPK. It is involved in a number of cellular processes such as inflammation, stress responses, nuclear export, cell proliferation, and regulation of gene expression. It mediates both ERK and p38 MAPK-dependent neutrophil responses, participates in TNFA-stimulated exocytosis of secretory vesicles in neutrophils, and plays a role in phagocytosis-induced respiratory burst activity. Another one of its major substrates is HSP27, a protein responsble for stimulating actin polymerization in order to facilitate the recovery from cytoskeleton destruction during cellular stress. Over-expression of the gene has been linked to Multiple Myeloma resistance to chemotherapy, and it has been found to play a role in neuroinflammatory and neurodegenerative diseases such as Alzheimer's.
應用類型
WB | AM
免疫原
人 MAPKAPK2 (AA219-226)蛋白Thr222殘基附近磷酸化肽
來源宿主
兔
反應性
人
保存建議
廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍11219多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，Str
