- 中文名稱
絲裂原和應激激活的蛋白激酶1抗體
- 英文名字
- MSK1 Antibody (pSer212): Dylight 594
- 供應商
- StressMarq
- 產品貨號
- SPC-1031D-DY594
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- StressMarq中國區現貨中心已經建立，90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumour formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.
- 應用類型
- WB | AM
- 免疫原
- 人 MSK1 (AA209-215)蛋白Ser212殘基附近磷酸化肽
- 來源宿主
- 兔
- 反應性
- 人
- 保存建議
- 廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
- 其他
- StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍11628多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，Str
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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