HMGB1, also known as high mobility group box 1 protein, and functions much like histones as they are important chromatin proteins. In the nucleus, HMGB1 interacts with nucleosomes, transcription factors and histones. The presence of HMGB1 in the nucleus depends on postranslational modifications. Hyperacetylation on lysine residues causes it to translocate into the cytosol. HMGB1 is also secreted by immune cells and acts as a cytokine mediator of inflammation. The mechanism of inflammation and damae is its binding to TLR2. HMGB1 also interacts with P53 and has been proposed as a target for cancer therapy.
應用類型
WB | ELISA
免疫原
人HMGB1內段合成肽.
來源宿主
兔
反應性
人 | 小鼠 | 大鼠
保存建議
廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍16307多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，Str
