Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene. Nuclear factor kappa B (NFKB) is a transcription factor that is highly influenced by stress, free-radicals, UV light and hypoxia. Unsurprisingly, NFKB is essential for many human cancers, as it regulates the expression of many downstream proteins that regulate or modify cellular growth and development. NFKB effects on angiogenic pathways and reactive mechanisms to stress and damage are well established throughout literature. Atherosclerosis is partly attributed to the mis-regulation of NFKB in hypoxia. Arthritis is related to inflammation proteins regulated through NFKB. It also has been shown to be important in synapses in brain, leading to memory and cognitive ability or impairment. In all, NFKB is one of the fastest responding transcription factors in humans, and is likely to mediate many responsive events in diseases and injury recovery.
應用類型
WB | IHC | ICC/IF
免疫原
人 NF-kappaB p105/p50合成肽
來源宿主
兔
反應性
人 | 小鼠
保存建議
廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍17317多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，Str?吼
