Catenin B-1 also known as B-catenin is a protein that in humans is encoded by the CTNNB1 gene. B-catenin is the first characterized member of the B -catenin family. B-catenin contains 12 ARM repeats and has a dual function, depending on its localization. Cytoplasmic B-catenin is a critical component of E-cadherin/catenin adhesion complexes and regulates cadherin-dependent cell-cell interactions. When localized to the nucleus, B -catenin regulates binding to transcription factors from the TCF/LEF family, activating transcription. B -catenin is expressed in hair follicle cells such as those found in the inner and outer portions of the root sheaths, and the basal and peripheral matrix cells. Expression has also been observed in colon tissue. Defects in expression have been linked to the development of several tumors and cancers.
應用類型
WB
免疫原
人B-catenin 酪氨酸654磷酸化位置 (A-T-YP-A-A) 附近 (未磷酸化的).
來源宿主
兔
反應性
人 | 小鼠 | 大鼠
保存建議
廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍17673多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，Str?吼
