GABARAPL1, one of the proteins belonging to the GABARAP (GABA(A) receptor-associated protein) family, is highly expressed in the central nervous system and implicated in processes such as receptor and vesicle transport as well as autophagy. The proteins that make up the GABARAP family demonstrate conservation of their amino acid sequences and protein structures. In humans, GABARAPL1 shares 86% identity with GABARAP and 61% with GABARAPL2 (GATE-16) (1). GABARAPL1, or GABA(A) Receptor-Associated Protein Like 1, is a ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (2).
應用類型
WB | ICC/IF
免疫原
人 GABARAPL1羧基末端合成肽
來源宿主
兔
反應性
人 | 大鼠
保存建議
廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍及4859多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，Str
