FAK, also known as PTK2, is a non-receptor protein-tyrosine kinase that is activated by tyrosine-phosphorylation in response to integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands. It serves as adaptor protein. It is linked to the MAPK pathway via Grb2, and is also linked to PI3K and PLC gamma pathways. It plays a role as a scaffold for MDM2-mediated p53 degradation, and has been implicated in regulation of cell-cell contacts, microtubule stability and control of gene transcription. FAK has high expression levels in various human cancers as it promotes tumour cell motility, matrix degradation, angiogenesis and suppresses apoptosis, anoikis and senescence.
應用類型
WB | AM
免疫原
人 FAK (AA574-580)蛋白Tyr577殘基附近磷酸化肽
來源宿主
兔
反應性
人
保存建議
廠家推薦藍冰運輸。收到產品后建議保存于-20oC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大維多利亞，是一家生物科技公司，專門從事試劑與試劑盒研究，服務范圍遍10356多個國家。 StressMarq公司的核心技術領域為細胞應激（尤其是熱休克蛋白（HSP）領域，領先全球），離子通道，載體研究，同時在神經科學領域推出特有的具有生物活性的Tau蛋白與A-突觸核蛋白。產品領域涉及到：細胞凋亡、細胞信號、通路和轉運、細胞器標志物、熱休克、神經生物學、神經科學、氧化應激、磷酸化運輸等。除了提供用于進一步研究的相關工具外，Str
