Abrogates the deubiquitinating activity of the 19S proteasome regulatory particle by selectively inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14), resulting in accumulation of polyubiquitin in cells. Potential cancer therapeutic agent.
產品描述
Inhibitor of the 19S proteasome regulator associated deubiquitinating enzymes UCHL5 and USP14. Potential modulator of proteasome activity.
