E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. collaborates with atxn3 in the degradation of misfolded chaperone substrates: atxn3 restricting the length of ubiquitin chain attached to stub1/chip substrates and preventing further chain extension. ubiquitinates nos1 in concert with hsp70 and hsp40. modulates the activity of several chaperone complexes, including hsp70, hsc70 and hsp90. mediates transfer of non-canonical short ubiquitin chains to hspa8 that have no effect on hspa8 degradation. mediates polyubiquitination of dna polymerase beta (polb) at 'lys-41', 'lys-61' and 'lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the huwe1/arf-bp1-dependent monoubiquitination and leading to polb-degradation by the proteasome. mediates polyubiquitination of cyp3a4. ubiquitinates epha2 and may regulate the receptor stability and activity through proteasomal degradation. negatively regulates the suppressive function of regulatory t-cells (treg) during inflammation by mediating the ubiquitination and degradation of foxp3 in a hspa1a/b-dependent manner (pubmed:23973223).
產品描述
該STUB1 ELISA Kit (Mouse)的產品描述請參考該產品的說明書
產品特點
ELISA試劑盒
保存建議
2°C to 8°C, -20°C
其他
Aviva Systems Biology總部位于加利福尼亞州圣迭戈，在中國北京設有辦公室，專注于為研究需求提供多克隆和單克隆抗體、ELISA試劑盒、蛋白質和定制服務。Aviva Systems Biology生產了24,000種經過驗證的多克隆抗體，并提供近20,000種ELISA試劑盒，定制實驗室服務包括蛋白表達和純化、抗體開發，以及ELISA的開發、驗證和生產。Aviva Systems Biology為與獨特物種和靶標相關的研究提供獨特工具，研究領域包括轉錄因子、癌癥、心血管、細胞生物學、DNA損傷和修復、表觀遺傳學、信號轉導、細胞分化、干細胞生物學等等。
