Zonulin（連蛋白）是一種參與上皮和內(nèi)皮屏障功能調(diào)節(jié)的蛋白質(zhì)，對腸粘膜細(xì)胞緊密連接的調(diào)節(jié)對于維持屏障內(nèi)環(huán)境的平衡至關(guān)重要，zonulin是目前唯一已知的細(xì)胞間緊密連接的生理調(diào)節(jié)劑，參與大分子的運(yùn)輸和耐受/免疫反應(yīng)平衡。當(dāng)連蛋白與腸的上皮細(xì)胞結(jié)合時(shí)，會(huì)誘導(dǎo)信號級聯(lián)。這種級聯(lián)分解了腸壁的細(xì)胞旁緊密連接。腸壁的緊密連接是允許分子從腸腔轉(zhuǎn)移到血流的兩種方式之一，反之亦然。當(dāng)腸道中的連蛋白水平增加并失去平衡時(shí)，這些連接點(diǎn)會(huì)打開得更寬，并保持更長時(shí)間。這些加寬的入口點(diǎn)允許較大的大分子進(jìn)入血液或腸腔。通過這些缺口的分子可以增加身體的自然免疫反應(yīng)，引起炎癥和一些自身免疫性疾病。

與 Zonulin 水平升高相關(guān)的疾病：

• 1型糖尿病

• 類風(fēng)濕關(guān)節(jié)炎

• 乳糜瀉

• 肝病

作為專業(yè)的生命科學(xué)醫(yī)藥原料供應(yīng)商，艾美捷科技為您推薦Immundiagnostik榮譽(yù)產(chǎn)品，連蛋白Zonulin檢測試劑盒：適用于血清（Serum）和糞便（stool）樣本！

* Immundiagnostik榮譽(yù)出品..僅供科研使用，不得用于醫(yī)療.

Zonulin產(chǎn)品已發(fā)表文章：

• Parker, Jim, Claire O’brien, and Jason Hawrelak. "A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome." Obstetrics & Gynecology Science 65.1 (2022): 14-28.

• Kleppe, Malin M., et al. "Intestinal barrier integrity in anorexia nervosa (a pilot study)." International Journal of Eating Disorders (2022).

• Meira de-Faria, Felipe, et al. "Colonic paracellular permeability and circulating zonulin-related proteins." Scandinavian Journal of Gastroenterology 56.4 (2021): 424-431.

• Tatucu-Babet, Oana A., et al. "Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults." Nutrition Research 78 (2020): 82-92.

• Xu, Yiyi, et al. "Inflammatory bowel disease and biomarkers of gut inflammation and permeability in a community with high exposure to perfluoroalkyl substances through drinking water." Environmental Research 181 (2020): 108923.

• Scherf, Katharina Anne, et al. "Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers." Clinical and translational allergy 9.1 (2019): 1-12.

• Kanerva, Sonja. "Assessment of immunological methods for quantification of human zonulin and the effects of intestinal bacteria on zonulin secretion in vitro." (2019).

• Ajamian, Mary, et al. "Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems." PloS one 14.1 (2019): e0210728.

• Shariatpanahi, Zahra Vahdat, et al. "Effects of early enteral glutamine supplementation on intestinal permeability in critically ill patients." Indian Journal of Critical Care Medicine: Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine 23.8 (2019): 356.

• Scheffler, Lucas, et al. "Widely used commercial ELISA does not detect precursor of haptoglobin2, but recognizes properdin as a potential second member of the zonulin family." Frontiers in endocrinology 9 (2018): 22.

• Mokkala, K., et al. "Evaluation of serum zonulin for use as an early predictor for gestational diabetes." Nutrition & diabetes 7.3 (2017): e253-e253.