蛋白質(zhì)聚集（Protein Aggregation）是蛋白因錯誤折疊而導(dǎo)致構(gòu)象發(fā)生變化形成聚集，使蛋白失活，在生物技術(shù)和制藥領(lǐng)域，這些聚集會嚴(yán)重影響蛋白的生產(chǎn)和應(yīng)用，是蛋白類藥物研發(fā)和商業(yè)化過程中一個重要的挑戰(zhàn)之一。聚集體在蛋白質(zhì)產(chǎn)品開發(fā)和生產(chǎn)過程的所有階段都可以觀察到，如蛋白表達(dá)、純化、凍干等。此外蛋白聚集體可能存在潛在增強(qiáng)免疫原性的風(fēng)險(xiǎn)。生物制藥行業(yè)一直都希望在生物工藝中找到新的方法，可用于檢測、追蹤、定量分析影響蛋白聚集的因素。

如何準(zhǔn)確高效地定量分析生物制品中的蛋白質(zhì)聚集情況呢？作為專業(yè)的生命科學(xué)醫(yī)藥原料供應(yīng)商，艾美捷科技為您推薦Enzo Life Sciences（Enzo）榮譽(yù)出品，PROTEOSTAT Protein aggregation assay（ENZ-51023）

*** 該產(chǎn)品僅用于科研實(shí)驗(yàn).

PROTEOSTAT Protein aggregation assay

提供了一種可靠、簡便、精確的測定方法，用于監(jiān)測溶液中的肽和蛋白質(zhì)聚集情況。

*PROTEOSTAT 蛋白質(zhì)聚集標(biāo)準(zhǔn)品（ENZ-51039）是wei一可商用的檢測痕量蛋白質(zhì)聚集體水平的穩(wěn)定、高質(zhì)量標(biāo)準(zhǔn)品。易于使用 -只需加水！

蛋白質(zhì)聚集檢測試劑盒，特點(diǎn)：

• 一種簡單、敏感、均勻的熒光檢測方法

• 經(jīng)過驗(yàn)證可用于微板或流式細(xì)胞儀平臺

• 以IgG為基準(zhǔn)進(jìn)行了廣泛的測試

• 優(yōu)化蛋白質(zhì)配方的緩沖劑和輔料

• 在廣泛的pH值和離子強(qiáng)度范圍內(nèi)表現(xiàn)良好

• 與PROTEOSTAT蛋白質(zhì)聚集標(biāo)準(zhǔn)品一起使用，可精確定量溶液中的聚集蛋白。

蛋白質(zhì)聚集檢測試劑盒，應(yīng)用：

• 鑒別蛋白聚集抑制劑

• 監(jiān)控大包裝產(chǎn)品和反復(fù)凍融引起的蛋白聚集

• 確定病毒滅活后的儲存條件

• 優(yōu)化蛋白制劑中緩沖液和賦形劑的配方

• 確定純化后的儲存條件

蛋白質(zhì)聚集檢測試劑盒，結(jié)果展示：

相關(guān)產(chǎn)品推薦：

PROTEOSTAT 蛋白質(zhì)聚集檢測試劑盒，ENZ-51023發(fā)表文章

• Cell-Instructive Surface Gradients of Photoresponsive Amyloid-like Fibrils: A.M. Bender, et al.; ACS Biomater. Sci. Eng. 7, 4798 (2021), Abstract;

• Characterization of Protein Aggregates, Silicone Oil Droplets, and Protein-Silicone Interactions using Imaging Flow Cytometry: C. Probst; J. Pharm. Sci. 109, 364 (2020), Abstract;

• Endoplasmic reticulum chaperone calmegin is upregulated in aldosterone-producing adenoma and associates with aldosterone production: K. Itcho, et al.; Hypertension 75, 492 (2020), Abstract;

• Monitoring plasma protein aggregation during aging using conformation-specific antibodies and FTIR spectroscopy: S. Magalhaes, et al.; Clin. Chim. Acta 502, 25 (2020), Application(s): Protein aggregation in human plasma samples, Abstract;

• PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation: T. Shimizu, et al.; Sci. Rep. 10, 20094 (2020), Abstract; Full Text

• The polyphenol quercetin protects from glucotoxicity depending on the aggresome in Caenorhabditis elegans: M. Civelek, et al.; Eur. J. Nutr. 59, 485 (2020), Application(s): Protein aggregation in solution, Abstract;

• Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation: D. Laor, et al.; Nat. Commun. 10, 62 (2019), Abstract; Full Text

• Transthyretin amyloid fibril disrupting activities of extracts and fractions from Juglans mandshurica maxim. var. cordiformis (Makino) kitam: N. Chaudhary, et al.; Molecules 24, 500 (2019), Application(s): Aged amyloid fibrils, Abstract; Full Text

• Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway: Y.L. Wu, et al.; Free Radic. Biol. Med. 115, 309 (2018), Abstract;

• Discovering putative prion-like proteins in Plasmodium falciparum: A computational and experimental analysis: I. Pallares, et al.; Front. Microbiol. 9, 1737 (2018), Application(s): P. falciparum culture, Abstract; Full Text

• High Throughput Differential Scanning Fluorimetry (DSF) Formulation Screening with Complementary Dyes to Assess Protein Unfolding and Aggregation in Presence of Surfactants: S.M. McClure, et al.; Pharm. Res. 35, 81 (2018), Abstract;

• The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation: M.H. Nawaz, et al.; BioSci. Rep. 38, BSR20171666 (2018), Application(s): Aggregation propensity assessed by DSF, Abstract; Full Text

• Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia: M. Tong, et al.; Sci. Rep. 7, 6694 (2017), Application(s): Protein aggregation in extracts from placental extracellular vesicles, Abstract; Full Text

• Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum: M. Ye, et al.; Front. Pharmacol. 8, 148 (2017), Abstract; Full Text

• Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins: A. Apicella, et al.; Colloids Surf. B Biointerfaces 156, 221 (2017), Application(s): Aggregation of enaml matrix derivative (EMD) proteins, Abstract;

• Trans ε-viniferin is an amyloid-β disaggregating and anti-inflammatory drug in a mouse primary cellular model of Alzheimer's disease: E. Vion, et al.; Mol. Cell. Neurosci. 88, 1 (2017), Abstract;

• ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation: J.H. Seo, et al.; Nat. Commun. 7, 12882 (2016), Application(s): , Abstract; Full Text

• BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo: S.J. Bultman, et al.; Cardiovasc. Pathol. 25, 258 (2016), Abstract;

• Cardiomyocyte-specific human Bcl2-associated anthanogene 3 P209L expression induces mitochondrial fragmentation, Bcl2-associated anthanogene 3: M.T. Quintana, et al.; Am. J. Pathol. 186, 1989 (2016), Application(s): Lysates from cardiac tissues, Abstract; Full Text

• Interfacial dilatational deformation accelerates particle formation in monoclonal antibody solutions: G.L. Lin, et al.; Soft Matter 12, 3293 (2016), Abstract;

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