Transferrin is a monomeric glycoprotein found in plasma at an average concentration of 250 mg/100 ml. The specific iron-binding protein in plasma, it has a role in the transportation and distribution of iron among the body organs, in iron metabolism and prevention of iron loss via the kidneys. Stored in bone marrow as Tf-bound iron, it also possesses bacteriostatic and fungistatic activity. Clinically, decreases in transferrin are observed in congenital disorders, newborns, inflammatory diseases, hypoproteinemias and nephrotic syndrome; increases are found in pregnancy, iron-deficiency anemias, and inoculation hepatitis. Transferrin is required by all types of cells in cultures for maximal growth. It is, therefore, an important transport factor used in defined culture media.

Synonym: Human transferrin, Siderophilin

Storage: <= -20°C

Purity: >=95% by SDS-PAGE

Iron Content: >= 1100 ug per gram

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Citations:

Enns, Caroline A., Riffat Ahmed, Jiaohong Wang, Akiko Ueno, Christal Worthen, Hidekazu Tsukamoto, and An-Sheng Zhang. "Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway." PloS one 8, no. 4 (2013): e60534.

Ref:

MacGillivray, R.T.A. et al. 1982 Proc. Natl. Acad. Sci. USA. 79,2504; Rivat,C. et al. 1992 J. Chromatogr. 576,71

轉(zhuǎn)鐵蛋白是一種單體糖蛋白，存在于血漿中，平均濃度為250mg/100ml。血漿中的特異性鐵結合蛋白，在鐵在身體器官之間的運輸和分布、鐵代謝和預防腎臟鐵流失方面發(fā)揮作用。它以Tf結合鐵的形式儲存在骨髓中，還具有抑菌和抑菌活性。臨床上，先天性疾病、新生兒、炎癥性疾病、低蛋白血癥和腎病綜合征中觀察到轉(zhuǎn)鐵蛋白的減少；妊娠、缺鐵性貧血和接種肝炎的發(fā)病率都有所增加。培養(yǎng)物中所有類型的細胞都需要轉(zhuǎn)鐵蛋白才能最大限度地生長。因此，它是特定培養(yǎng)基中使用的重要運輸因素。

艾美捷人血漿轉(zhuǎn)鐵蛋白基本信息：

貨號：16-16-032001

同義詞：人轉(zhuǎn)鐵蛋白、側(cè)營養(yǎng)因子

儲存條件：≤ -20°C

純度：≥95%（通過SDS-PAGE測定）

鐵含量：≥每克1100微克

經(jīng)FDA要求的檢測，顯示用于制備的血漿對HBsAg、抗-HCV、抗-HBc無反應，并且抗-HIV 1 & 2呈陰性。

不得用于人體或任何藥物用途。僅限研究使用。

SDS-PAGE：

4-12%Bis-Tris-NuPAGE凝膠

低分子量標準

轉(zhuǎn)鐵蛋白 - 5 微克（非還原條件/無需加熱）

轉(zhuǎn)鐵蛋白 - 10 微克（非還原條件/無需加熱）

轉(zhuǎn)鐵蛋白 - 20 微克（非還原條件/無需加熱）

人血漿轉(zhuǎn)鐵蛋白文獻參考：

MacGillivray, R.T.A. et al. 1982 Proc. Natl. Acad. Sci. USA. 79,2504; Rivat,C. et al. 1992 J. Chromatogr. 576,71  

Athens Research & Technology 的人血漿轉(zhuǎn)鐵蛋白都能發(fā)揮關鍵作用。對于從事細胞生物學研究的科學家來說，它是優(yōu)化細胞培養(yǎng)條件的得力助手。在血液學和免疫學領域，有助于深入了解鐵代謝與免疫系統(tǒng)之間的微妙關系。而在腫瘤研究中，轉(zhuǎn)鐵蛋白的異常表達和功能失調(diào)往往與腫瘤的發(fā)生、發(fā)展和轉(zhuǎn)移密切相關。