異戊二烯類化合物 是一類多樣化的天然產(chǎn)物，是所有細(xì)胞中必不可少的成分。異戊二烯類化合物是由簡單的前體異戊二烯焦磷酸（IPP）和二甲基烯丙基焦磷酸（DMAPP）生物合成而來的。真核生物、真菌和某些革蘭氏陽性菌通過甲羥戊酸（MVA）途徑產(chǎn)生IPP，而革蘭氏陰性菌和某些革蘭氏陽性菌則利用非甲羥戊酸途徑或2-C-甲基-D-赤蘚糖醇-4-磷酸（MEP）途徑。**1-羥基-2-甲基-2-丁烯-4-基-4-二磷酸（HDMAPP或HMBPP）是非甲羥戊酸途徑中的一個中間體，由2-C-甲基-D-赤蘚糖醇-2,4-環(huán)磷酸（cMEPP）**通過IspG（GcpE）生物合成而來。它是IspH（LytB）的底物，生成IPP和DMAPP。此外，HDMAPP是迄今為止發(fā)現(xiàn)的最有效的VγVδ T細(xì)胞激活劑。

艾美捷[干冰]1-羥基-2-甲基-2-丁烯-4-基-4-二磷酸(HDMAPP)：

貨號：I-M055

分類：生化試劑

篩選：異戊二烯焦磷酸、MEP途徑

CAS編號：396726-03-7

分子式：C5H21N3O8P2

分子量（g/mol）：313.18

純度：95%

儲存：-20°C或更低

運輸溫度：凝膠冰

[干冰]1-羥基-2-甲基-2-丁烯-4-基-4-二磷酸(HDMAPP)文獻(xiàn)參考：

1) deBarros, A., M. Chaves-Ferreira, et al. (2011). “CD70–CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes.” European Journal of Immunology 41(1): 195.

2) Spencer, C. T., G. Abate, et al. (2008). “Only a Subset of Phosphoantigen-Responsive γ9δ2 T Cells Mediate Protective Tuberculosis Immunity.” The Journal of Immunology 181(7): 4471-4484.

3) Moens, E., M. Brouwer, et al. (2011). “IL-23R and TCR signaling drives the generation of neonatal Vγ9Vδ2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17.” J Leukoc Biol 89(5): 743-52.

4) Hsiao, C.-H. C. and A. J. Wiemer (2018). “A power law function describes the time- and dose-dependency of Vγ9Vδ2 T cell activation by phosphoantigens.” Biochem Pharmacol 158: 298-304.

5) Rodrigues, N. V., et al. (2018). “Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells.” Cancer immunology research 6(4): 448-457.

6) Kouakanou, L., et al. (2019). “Vitamin C promotes the proliferation and effector functions of human γδ T cells.” Cellular & Molecular Immunology. DOI:10.1038/s41423-019-0247-8