PI(3,5)P2 diC8（磷脂酰肌醇3,5-二磷酸二油酸酯） 是一種合成的、純化的二油酸基PI(3,5)P2。

磷脂酰肌醇（PIPns） 是細胞膜的次要成分，但卻是細胞通信中不可或缺的信號分子。磷脂酰肌醇3,5-二磷酸 含量極低，對于從溶酶體和晚期內體向高爾基體的逆向膜運輸至關重要，并且參與自噬過程。PI(3,5)P2的水平由5-激酶PIKfyve和5-磷酸酶Fig4/Sac3調控，其失調與多種人類神經病變有關（例如夏科-馬里-圖斯病）。

艾美捷[干冰]磷脂酰肌醇(3,5)二磷酸二辛酯(PI(3,5)P2 diC8)：

貨號：P-3508

關鍵詞：二油酸基磷脂酰肌醇3,5-二磷酸、PtdIns(3,5)P2 (8:0/8:0)、PI(3,5)P2 C8

分類：脂質

篩選：diC8、磷脂酰肌醇、PI(3,5)P2

CAS編號：299216-96-9

分子式：C25H44Na5O19P3

分子量（g/mol）：856.48

純度：95%

儲存：-20°C或更低

運輸溫度：根據(jù)目的地不同，采用干冰或凝膠冰運輸

[干冰]磷脂酰肌醇(3,5)二磷酸二辛酯(PI(3,5)P2 diC8)文獻參考：

1. Marcus, S. L., M. R. Wenk, et al. (2001). “A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation.” FEBS Lett 494(3): 201-7

2. Johnson, L. M., K. M. James, et al. (2005). “Identification of Key Residues in the A-Raf Kinase Important for Phosphoinositide Lipid Binding Specificity.” Biochemistry 44(9): 3432-3440.

3. Ikonomov, O. C., D. Sbrissa, et al. (2009). “Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.” J Biol Chem 284(36): 23961-71.

4. Silswal, N., et al. (2011). “Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction.” Am J Physiol Heart Circ Physiol 300(6): H2016-2026.

5. Kirsch, S. A., et al. (2018). “Phosphatidylinositol-3, 5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2.” Cellular and Molecular Life Sciences: 1-13.