Montana Molecular-PIP2檢測試劑盒的性能：

基因編碼，低毒性

PIP2傳感器和對照組包含在BSL-1級(jí)的BacMam載體中，可在多種細(xì)胞中有效表達(dá)

單通道讀數(shù)可以與額外的GPCR檢測結(jié)合使用

實(shí)時(shí)動(dòng)態(tài)讀數(shù)

多重檢測試驗(yàn)：

結(jié)合紅色和綠色傳感器，可以同時(shí)測量多個(gè)GPCR信號(hào)通路

艾美捷 Montana Molecular-PIP2檢測試劑盒簡單的操作流程：

無需細(xì)胞裂解

單通道讀數(shù)

BSL-1級(jí)載體

控制表達(dá)水平

Montana Molecular-PIP2檢測試劑盒文獻(xiàn)參考：

L. Brueggemann, et al. Structural Determinants of Kv7.5 Potassium Channels that Confer Changes in Phosphatidylinositol 4,5-Biphosphate (PIP2) Affinity and Signaling Sensitivity in Smooth Muscle Cells. Molecular Pharmacology. March 2020.

L.Liu, et al. Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation. J.Neurosci. May 2019.

Alexey N. Pronin, Qiang Wang and Vladlen Z. Slepak Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor Molecular Pharmacology Nov. 2018

Y. Ding, et al. Ratiometric biosensors based on dimerization dependent fluorescent protein exchange. Nature Methods, 2015.

P. Tewson, et al. A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells. J. Biomolecular Screening 18, 2013.

Montana Molecular產(chǎn)品主要包括GPCR檢測、細(xì)胞應(yīng)激和毒性相關(guān)檢測工具，為客戶提供了長時(shí)間內(nèi)觀察候選藥物對細(xì)胞過程影響的能力。艾美捷科技是Montana Molecular的中國代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。