RIP3（RIPK3，Receptor Interacting Protein 3），受體相互作用蛋白3，是一種重要的蛋白質(zhì)，在細(xì)胞凋亡過程中起著關(guān)鍵作用。近年來，RIP3蛋白研究取得了顯著進(jìn)展。首先，研究人員發(fā)現(xiàn)RIP3蛋白與許多其他重要的蛋白質(zhì)相互作用，從而參與了細(xì)胞凋亡的誘導(dǎo)和調(diào)節(jié)。其中，一些研究表明RIP3蛋白與蛋白質(zhì)復(fù)合物Necrosome相關(guān)，這是一個(gè)重要的細(xì)胞凋亡誘導(dǎo)機(jī)制。此外，RIP3蛋白也與細(xì)胞凋亡調(diào)節(jié)因子、蛋白酶以及其他蛋白質(zhì)相互作用，參與了細(xì)胞凋亡的誘導(dǎo)和調(diào)節(jié)。隨著新病毒如SARS-CoV-2的出現(xiàn)以及流感、MPOX和RSV等已知病毒的激增，RIPK 3已成為研究和治療的首要靶點(diǎn)，但最近的研究表明，它是幾種炎癥性疾病、退行性疾病甚至癌癥的可行靶點(diǎn)。   

艾美捷科技為您推薦ProSci，經(jīng)敲除驗(yàn)證的RIP3 / RIPK3抗體（貨號(hào)PSI-2283），已被廣泛引用，在抗體引文跟蹤器CiteAb上被引用多達(dá)171次，在Bioz上被引用多達(dá)165次。我們抗體的可靠性促成了它的受歡迎程度，在許多頂級(jí)期刊上發(fā)表的研究中，包括《Nature》《Cell》《Nature Medicine》。至關(guān)重要的是，我們的抗體已經(jīng)參與了很多與治療學(xué)開發(fā)相關(guān)的研究，以及冠狀病毒和COVID-19療法有關(guān)的研究。  

以下幾篇文章展示了在您的研究中使用ProSci抗體的療效：

• Karki R, Lee S, Mall R, et al. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection. Sci Immunol. 2022;7(74):eabo6294. doi:10.1126/sciimmunol.abo6294

• Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021;597(7876):415-419. doi:10.1038/s41586-021-03875-8

• Zhang T, Yin C, Boyd DF, et al. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020;180(6):1115-1129.e13. doi:10.1016/j.cell.2020.02.050

• Zheng M, Karki R, Vogel P, Kanneganti TD. Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell. 2020;181(3):674-687.e13. doi:10.1016/j.cell.2020.03.040

RIP3 / RIPK3抗體相關(guān)產(chǎn)品推薦：

• RIPK1 ，貨號(hào)：PSI--5389（50篇以上文章）

• MLKL ，貨號(hào)：PSI--14-026

• TRIF ，貨號(hào)：PSI--3173（50篇以上文章）

• FADD ，貨號(hào)：PSI--18-232, 18-273 (KO Validated)

• cFLIP ，貨號(hào)：PSI--1159（50篇以上文章）

• NLRP3 ，貨號(hào)：PSI--5447（50篇以上文章）

• NOD2 ，貨號(hào)：PSI--2513（50篇以上文章）

• Caspase8 ，貨號(hào)：PSI--3473（50篇以上文章）

RIP3 / RIPK3抗體更多發(fā)表文章：

• He et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009;137(6):1100-11. PMID: 19524512

• Zhang et al. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature. 2011;471(7338):373-6. PMID: 21368761

• Narayan et al. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature. 2012;492(7428):199-204. PMID:   23201684

• Li et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23(9):1428-47. doi:10.1038/cdd.2016.21. Epub 2016. PMID:        26943325

• Yang et al. Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis. Cell Death Dis. 2017;8(10):e3084. doi:10.1038/cddis.2017.483. PMID: 28981102

• Ramachandran et al. Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology. 2013;58(6):2099-108. PMID: 23744808

• Li et al. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 2012 ;150(2):339-50. PMID:        22817896

• Vitner et al. RIPK3 as a potential therapeutic target for Gaucher's disease. Nat Med. 2014;20(2):204-8. PMID: 24441827

• Wang et al. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014;15(12):1126-33. PMID: 25326752

• Onizawa et al. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015;16(6):618-27. PMID: 25939025

• Murphy et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 2013;39(3):443-53. PMID: 24012422

• Nogusa et al. RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Cell Host Microbe 2016;20(1):13-24. PMID: 27321907

• Pearson et al. EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation. Nat Microbiol. 2017 ;2:16258. PMID: 28085133

• Yang et al. The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity? Hepatology. 2016;64(1):311-2PMID: 26418225

• Qu et al. Graphene oxide induces toll-like receptor 4 (TLR4)-dependent necrosisin macrophages. ACS Nano. 2013;7(7):5732-45.PMID: 23734789

• Gandhirajan et al. Blockade of NOX2 and STIM1 signaling limits Lipo polysaccharide-induced vascular inflammation. J Clin Invest. 2013;123(2):887-902. PMID: 23348743

• Fortes et al. Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood. 2012;119(10):2368-75. PMID: 22262768

• Xu et al. The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited. Nat Commun. 2017;8(1):425. PMID: 28871172

• Karunakaran et al. Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Sci Adv. 2016 ;2(7):e1600224. PMID: 27532042

• Chen et al. Mechanisms of necroptosis in T cells. J Exp Med. 2011 Apr 11;208(4):633-41.PMID: 21402742

ProSci Incorporated于1998年成立于美國(guó)加州圣地亞哥市,從事抗體等科研試劑的研發(fā)、生產(chǎn)和銷售。產(chǎn)品涵蓋了細(xì)胞凋亡、信號(hào)轉(zhuǎn)導(dǎo)、免疫、腫瘤、細(xì)胞生物、神經(jīng)生物、傳染病等領(lǐng)域。ProSci擁有超過30000種單克隆抗體和多克隆抗體。ProSci的抗體大都經(jīng)免疫親和層析純化,具有高純度、高親和力、特異性強(qiáng)等特點(diǎn),所有的ProSci抗體都經(jīng)過了嚴(yán)格的驗(yàn)證測(cè)試和質(zhì)量控制,已保證高質(zhì)量的產(chǎn)品。此外,ProSci還提供標(biāo)記二抗,重組蛋白,細(xì)胞和組織裂解液,細(xì)胞涂片,組織切片,多肽等產(chǎn)品與抗體配套使用。