用熒光成像監(jiān)測細胞核中cAMP的變化。基因編碼并包裝在BacMam病毒載體中，可輕松轉(zhuǎn)導(dǎo)到多種細胞類型中，包括原代和iPSC衍生的細胞系。綠色熒光核靶向cAMP傳感器也是可用的。

艾美捷 Montana Molecular紅核靶向cADDis cAMP#U0211R包含的材料：

紅色核靶向cADDis cAMP傳感器BacMam

丁酸鈉，500 mM水溶液

帶有核綠色標簽的β2腎上腺素受體BacMam

異丙腎上腺素10 mM，溶于10 mM鹽酸中

用熒光成像監(jiān)測細胞核中cAMP的變化。基因編碼并包裝在BacMam病毒載體中，便于轉(zhuǎn)導(dǎo)到多種細胞類型中。

Montana Molecular-cAMP部分出版參考：

J. Xu, et al. An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure. Science Advances. March 2024 (bioRxiv)

J. Alvarado et al. Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding. Neuron. February 2024. (bioRxiv)

H. Hamzeh, et al. Deciphering rapid cell signaling and control of cell motility by reverse opto-chemical engineering. bioRxiv. February 2024.

N. Philip. Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension. Lung Cellular and Molecular Physiology. January 2024.

L. Ripoll & M. von Zastrow. Spatial organization of adenylyl cyclase and its impact on dopamine signaling in neurons. bioRxiv. December 2023.

T. Richardson, Y. Pettway, et al. Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles. Journal of Visualized Experiments. November 2023.

相關(guān)產(chǎn)品：

#U0205G Green Upward cADDis cAMP (Promoter CAG)

#D0331G Green Membrane-Targeted DAG

#U0200R Red Up cADDis cAMP Assay Kit

#U0300R Red Up DAG Assay Kit

Montana Molecular產(chǎn)品主要包括GPCR檢測、細胞應(yīng)激和毒性相關(guān)檢測工具，為客戶提供了長時間內(nèi)觀察候選藥物對細胞過程影響的能力。艾美捷科技是Montana Molecular的中國代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。