人腸道病毒71型(EV71)是手足口病的主要病原體

        腸病毒71型（enterovirus 71，EV71）病毒是一種引起手足口病的主要致病病原體，更可導(dǎo)致無菌性腦膜炎，腦干腦炎，以及脊髓灰質(zhì)炎樣麻痹等多種神經(jīng)系統(tǒng)相關(guān)疾病。EV71是小RNA病毒科腸道病毒屬成員，病毒基因組由大約7408個(gè)核苷酸組成的單股正鏈RNA，具有侵染性。病毒外殼由四個(gè)外殼蛋白（VP1、VP2、VP3和VP4）組成，其中外殼蛋白VP1 為最重要的抗原決定簇。

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       EV71-VP1抗體實(shí)驗(yàn)應(yīng)用：

        《1》EV71-VP1抗體WB檢測：     

       《2》EV71-VP1抗體ELISA檢測抗體：

       已發(fā)表文獻(xiàn)：

•        Fibronectin facilitates EV71 infection by mediating its entry.

He QQ, Ren S, Xia ZC, Cheng ZK, Peng NF, Zhu Y.J Virol. 2018 Feb 21. [Epub ahead of print]   

•        HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.

Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, Cai Y, Wan P, Xiong Y, Liu F, Wu K, Liu Y, Wu J.J Immunol. 2017 Nov 1;199(9):3280-3292. doi: 10.4049/jimmunol.1700376. Epub 2017 Sep 27.   

•        Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy.

Wang H, Li K, Ma L, Wu S, Hu J, Yan H, Jiang J, Li Y.Virol J. 2017 Jan 11;14(1):2.   

•        A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71.

Liou AT, Wu SY, Liao CC, Chang YS, Chang CS, Shih C1.Sci Rep. 2016 Aug 8;6:31151.   

•        Early growth response-1 facilitates enterovirus 71 replication by direct binding to the viral genome RNA.

Song Y, Cheng X, Yang X, Zhao R, Wang P, Han Y, Luo Z, Cao Y, Zhu C, Xiong Y, Liu Y, Wu K, Wu JInt J Biochem Cell Biol. 2015 Feb 24;62:36-46. doi: 10.1016/j.biocel.2015.02.012.   

•        PolyC-Binding Protein 1 Interacts with 5'-Untranslated Region of Enterovirus 71 RNA in Membrane-Associated Complex to Facilitate Viral Replication.

Luo Z, Dong X, Li Y, Zhang Q, Kim C, Song Y, Kang L, Liu Y, Wu K, Wu JPLoS One. 2014 Jan 29;9(1):e87491. doi: 10.1371/journal.pone.0087491. eCollection 2014.   

•        Human enterovirus 71 uncoating captured at atomic resolution.

Lyu K, Ding J, Han JF, Zhang Y, Wu XY, He YL, Qin CF, Chen RJ Virol. 2014 Mar;88(6):3114-26. doi: 10.1128/JVI.03029-13. Epub 2013 Dec 18.   

•        The highly conserved 5' untranslated region as an effective target towards the inhibition of Enterovirus 71 replication by unmodified and appropriate 2'-modified siRNAs.

Deng JX, Nie XJ, Lei YF, Ma CF, Xu DL, Li B, Xu ZK, Zhang GC.J Biomed Sci. 2012 Aug 13;19:73.   

•        Enterovirus 71 Disrupts Interferon Signaling by reducing the Interferon Receptor I.

Lu J, Yi L, Zhao J, Yu J, Chen Y, Lin MC, Kung HF, He ML.J Virol. 2012 Jan 18. [Epub ahead of print]   

•        Viral kinetics of Enterovirus 71 in human abdomyosarcoma cells.

       Lu J, He YQ, Yi LN, Zan H, Kung HF, He ML.World J Gastroenterol. 2011 Sep 28;17(36):4135-42.     艾美捷科技與國內(nèi)外優(yōu)秀的生物試劑供應(yīng)商保持著密切的合作關(guān)系，目前已成為眾多國際知名品牌的中國總代理或一級代理，主要包括：Abbkine、Merck Millipore、Origene、AAT Bioquest、Cayman Chemical、Abnova 、Biovision、ProSpec、Hycult Biotech 、Equitech-Bio、Trevigen、Alomone Labs、Epigentek、ImmunoReagents 、Jackson、SouthernBiotech、US Biological 、Caisson Labs等，可以在第一時(shí)間為用戶提供最前沿的專業(yè)資訊、完備的產(chǎn)品及物流服務(wù)。