Histone H2, K43ac Biotin Conjugated peptide - 000-006-K40-Histone H2, K43ac Biotin Conjugated peptide - 000-006-K40代理/參數(shù)/廠家-重組蛋白-艾美捷科技有限公司

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中文名稱: Histone H2, K43ac Biotin Conjugated peptide - 000-006-K40

英文名字: Histone H2, K43ac Biotin Conjugated peptide - 000-006-K40

供應(yīng)商: Rockland

產(chǎn)品貨號(hào): 000-006-K40

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/1mg

產(chǎn)品說明書: 點(diǎn)擊查看

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背景資料: The nucleosome is comprised of 146 bp of DNA wrapped around a series of histone proteins arranged as an octamer consisting of 2 copies of histone H2A, H2B, H3 and H4. Within the nucleosome core the histone proteins are covalent modified at specific residues predominantly within the N-terminal tail including lysine (acetylation, methylation, SUMOylation, and ubiquitinylation), arginine methylation and citrullination, serine and threonine phosphorylation, as well as proline isomerization. The lysine side chains can carry up to three methyl groups (mono-, di- and tri- methylated forms) and the arginine side chain can be monomethylated or can be dimethylated as the symmetric or asymmetric forms. The modifications show temporal, disease-specific, and other types of cell-specific regulation and there are specific families of enzymes that regulate the methylation, demethylation, acetylation, deacetylation and other modifications. Research has indicated that whereas the histone mark H3K4Me3 (tri-methyl lysine 4 of histone H3) localizes to gene promoter regions (it is associated with transcriptional activation) other modifications at H3K4 such as monomethyl is present predominantly at enhancer sequences. Specific marks have been associated with activation (H3K9Me1, H3K27Me1, and H4K20Me1) or repression (H3K9Me2 and Me3, H3K27Me2 and Me3, and H4K20Me2 and Me3) of genes. Monomethylation of H4 at K20, catalyzed by SET8, is essential to genome replication and stability. Multiple DNA breaks are associated with demethylation at this site, resulting in activation of p53 to avoid mitosis and aberrant chromosomal activity. In mammalian stem cells, Xist expression blocks the formation of H4K20me1, which is one of the first examples of a direct connection between chromatin and stem cell differentiation. Histone H2 are ideal for researchers interested in Chromatin Research, DNA replication Transcription Translation and Splicing, Epigenetics, Chromatin Modifiers, Histones and Modified Histones, DNA Repair, and HA Epitope Tags research.

序列: 該Histone H2, K43ac Biotin Conjugated peptide - 000-006-K40的詳細(xì)信息查看Rockland提供的產(chǎn)品說明書。

來源宿主: 該Histone H2, K43ac Biotin Conjugated peptide - 000-006-K40的詳細(xì)信息查看Rockland提供的產(chǎn)品說明書。

溶解建議: Restore with deionized water (or equivalent)

保存建議: Store vial at 2 - 8 ° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國(guó)費(fèi)城郊區(qū)的農(nóng)場(chǎng)保有近20種實(shí)驗(yàn)動(dòng)物。Rockland公司為生命科學(xué)領(lǐng)域提供豐富的、高質(zhì)量的抗體，包括載脂蛋白、細(xì)胞周期/凋亡、細(xì)胞因子、細(xì)胞信號(hào)蛋白、酶類、細(xì)胞外基質(zhì)、轉(zhuǎn)錄因子(NFkB)和泛素（Ubiquitin）等識(shí)別抗體，應(yīng)用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標(biāo)記二抗，應(yīng)用十分廣泛。