【干冰】Anti-Calreticulin (RABBIT) Antibody - 100-401-E99-【干冰】Anti-Calreticulin (RABBIT) Antibody - 100-401-E99代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 【干冰】Anti-Calreticulin (RABBIT) Antibody - 100-401-E99

英文名字: 【干冰】Anti-Calreticulin (RABBIT) Antibody - 100-401-E99

供應(yīng)商: Rockland

產(chǎn)品貨號: 100-401-E99

產(chǎn)品報價: ￥詢價/200uL

產(chǎn)品說明書: 點擊查看

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背景資料: Calreticulin is a multifunctional, highly conserved Ca2+ -binding protein that is localized to the endoplasmic reticulum (ER), but has also been detected in the nucleus and nuclear envelop. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. CRT’s three domains include a 180 residue N-terminal domain, a proline-rich P-domain (residues 189-288) that binds Ca2+ with high affinity and shares homology with calnexin (CNX) and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity. Recent studies suggest that this soluble ER protein has a multifunctional role. It appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. It has been shown to interact with the cytoskeleton and to be involved in the regulation of gene expression. Calreticulin may also play a role in cellular proliferation including its apparent activity in the proliferation of certain viruses within mammalian host cells, and it has also been shown to be induced in response to various types of cell stress including amino acid deprivation. Close interconnections among protein synthesis, gene expression and calcium signaling have been observed by many researchers in recent years. Calreticulin might be centrally located and therefore it crucially participates in the coordination of many functions by the cell. Studies also suggest its involvement in a few diseases such as systemic lupus erythematosus, rheumatoid arthritis, celiac disease, complete congenital heart block, and halothane hepatitis.

應(yīng)用類型: Immunohistochemistry,IF Microscopy,Immunoprecipitation,Western Blot,

免疫原: Calreticulin Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide of human calreticulin.

來源宿主: Rabbit

反應(yīng)性: Bovine (Bos Taurus); Canine (Dog); Cavia porcellus (Guinea Pig); Cricetinae (Hamster); Gallus gallus (Chicken); H. sapiens (Human); Leporidae (Rabbit); Mus musculus (Mouse); Ovis aries (Sheep); Rattus (Rat); Simiiformes (Monkey); Sus scrofa domesticus (Pig, Porcine, Swine)

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國費城郊區(qū)的農(nóng)場保有近20種實驗動物。Rockland公司為生命科學(xué)領(lǐng)域提供豐富的、高質(zhì)量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質(zhì)、轉(zhuǎn)錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應(yīng)用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標(biāo)記二抗，應(yīng)用十分廣泛。