【干冰】Anti-Hsc70 (Hsp73) (RABBIT) Antibody - 100-401-F49-【干冰】Anti-Hsc70 (Hsp73) (RABBIT) Antibody - 100-401-F49代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 【干冰】Anti-Hsc70 (Hsp73) (RABBIT) Antibody - 100-401-F49

英文名字: 【干冰】Anti-Hsc70 (Hsp73) (RABBIT) Antibody - 100-401-F49

供應(yīng)商: Rockland

產(chǎn)品貨號: 100-401-F49

產(chǎn)品報價: ￥詢價/100uL

產(chǎn)品說明書: 點擊查看

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背景資料: Hsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity. The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides. When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half. The structure of this ATP binding domain displays multiple features of nucleotide binding proteins. When cells are subjected to metabolic stress (e.g., heat shock) a member of the hsp 70 family, hsp 70 (hsp72), is expressed; hsp 70 is highly related to hsc70 (>90% sequence identity). Constitutively expressed hsc70 rapidly forms a stable complex with the highly inducible hsp70 in cells following heat shock. The interaction of hsc70 with hsp 70 is regulated by ATP. These two heat shock proteins move together in the cell experiencing stress. Furthermore, research on hsc70 has implicates it with a role in facilitating the recovery of centrosomal structure and function after heat shock.

應(yīng)用類型: Immunohistochemistry,IF Microscopy,Immunoprecipitation,Western Blot,

免疫原: Hsc70 (Hsp73) Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against a c-terminal region of human hsp73.

來源宿主: Rabbit

反應(yīng)性: Cricetinae (Hamster); H. sapiens (Human)

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國費城郊區(qū)的農(nóng)場保有近20種實驗動物。Rockland公司為生命科學(xué)領(lǐng)域提供豐富的、高質(zhì)量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質(zhì)、轉(zhuǎn)錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應(yīng)用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標(biāo)記二抗，應(yīng)用十分廣泛。