中文名稱

Leptomycin B (50 ug)

英文名字

Elactocin|LMB|Mantuamycin|NSC 364372, Leptomycin B, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,1E,12E,16Z,18E-nonadecapentaenoic acid

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

10004976-50

產(chǎn)品報(bào)價(jià)

￥24304/50 ug

產(chǎn)品說(shuō)明書

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產(chǎn)品新聞

背景資料

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 -exportin 1) with nuclear export signals -NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins -export factors). By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation. Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp..

產(chǎn)品描述

A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1; inhibits nuclear export of HIV-1 Rev -IC50 = 0.53)

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書確認(rèn)。

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