中文名稱

PDM 2 (500 mg)

英文名字

PDM 2, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene

供應商

Cayman

產(chǎn)品貨號

10006342-500

產(chǎn)品報價

￥16170/500 mg

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

The aryl hydrocarbon receptor -AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 uM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.

產(chǎn)品描述

The aryl hydrocarbon receptor -AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.{12907} PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a Ki of 1.2 nM.{12475} PDM 2 is inactive as a ligand for the estrogen receptor even at 100 uM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準確的產(chǎn)品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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