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中文名稱

抗黑皮質(zhì)素-4受體多克隆抗體

英文名字
Melanocortin-4 Receptor Polyclonal Antibody
供應(yīng)商
Cayman
產(chǎn)品貨號(hào)
10006355-500
產(chǎn)品報(bào)價(jià)
￥3206/500 μl
產(chǎn)品說(shuō)明書(shū)
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背景資料
Melanocortins are known to exert a broad array of physiological actions including melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis . These actions are mediated -differentially or concurrently) in part by a family of G-protein coupled receptors, the melanocortin receptors 1-5 -MC1R-MC5R). Melanocortin-4 receptor -MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain. Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation. Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity. All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE. Cayman s MC4R polyclonal antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.
應(yīng)用類型
WB and IHC -formalin-fixed paraffin-embedded sections); other applications not tested
免疫原
mouse melanocortin-4 receptor amino acids 21-33 -YGLHSNASESLGK)
來(lái)源宿主
rabbit
反應(yīng)性
Human MC4R+|Mouse MC4R+|Rat MC4R+
保存建議
其他
Cayman Chemical
注意
該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。
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