中文名稱

TGX-221 (100 ug)

英文名字

TGX-221, 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

10007349-100

產(chǎn)品報(bào)價(jià)

￥602/100 ug

產(chǎn)品說(shuō)明書(shū)

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背景資料

Phosphatidylinositol 3-kinase -PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol--3,4)-bisphosphate -PtdIns--3,4)-P2) and PtdIns--3,4,5)-P3). Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are 4 isoforms -p110.alpha., p110.beta., p110.delta., and p100.gamma.), and a p85 regulatory subunit. TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110.beta.. Inhibition appears to occur at the ATP binding site based on the observed increase in IC50 from 5 to ~50 nM at ATP concentrations of 50 uM and 1 mM, respectively. TGX-221 inhibits PtdIns--3,4)-P2 production in platelets with an IC50 of 50 nM. Selective inhibition of PI3K p110.beta. results in defective platelet thrombus formation and defines PI3K as a target for antithrombotic therapy.

產(chǎn)品描述

A potent, selective, and cell permable inhibitor of PI3K p110b; IC50 increases from 5 to ~50 nM at ATP concentrations of 50 uM and 1 mM, respectively; inhibits PtdIns--3,4)-P2 production in platelets with an IC50 value of 50 nM

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

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