中文名稱

Tetradecyl Phosphonate (5 g)

英文名字

Tetradecyl Phosphonate, tetradecylphosphonic acid

供應(yīng)商

Cayman

產(chǎn)品貨號

10007565-5

產(chǎn)品報價

￥5880/5 g

產(chǎn)品說明書

點擊查看

購買方式

產(chǎn)品新聞

背景資料

Lysophosphatidic acid -LPA) is a lipid signalling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase D, also known as autotaxin -ATX). LPA signals through four different G protein-coupled receptors, LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23. Activation of peroxisome proliferator-activated receptor .gamma. -PPAR.gamma.) by LPA has also been reported. Tetradecyl phosphonate is a pan-antagonist of LPA1, LPA2, and LPA3 receptors with IC50 values for inhibition of LPA-induced calcium mobilization of 10 uM, 5.5 uM, and 3.1 uM, respectively. At a concentration of 10 uM, tetradecyl phosphonate activates a PPAR.gamma. reporter construct 4-fold compared to controls and partially inhibits ATX with an IC50 of approximately 3 uM.

產(chǎn)品描述

A pan-antagonist of LPA1-3 receptors -IC50 = 10, 5.5, and 3.1 uM, respectively)

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

分享到：