Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Palmitoyl sphingomyelin is a form of sphingomyelin containing palmitate -16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and milk. Palmitoyl sphingomyelin interacts with cholesterol in ordered lipid domains -lipid rafts). Sphingomyelinases remove phosphorylcholine from palmitoyl sphingomyelin to produce C-16 ceramide. While ceramides commonly induce apoptosis, ceramides with different fatty acid chain lengths might direct distinct functions and, in some cases, reduce apoptosis.
產(chǎn)品描述
A form of sphingomyelin containing palmitate -16:0), the most common form of sphingomeylin found in eggs; interacts with cholesterol in lipid rafts; produces C-16 ceramide when processed by sphingomyelinases