13,14-dihydro-15-keto Prostaglandin D2-d4 -13,14-dihydro-15-keto PGD2-d4) contains four deuterium atoms at the 3, 3 , 4, and 4 positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11.beta.-hydroxy compounds which have also undergone .beta.-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.
產(chǎn)品描述
13,14-dihydro-15-keto Prostaglandin D2-d4 -13,14-dihydro-15-keto PGD2-d4) contains four deuterium atoms at the 3, 3 , 4, and 4 positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-mass spectrometry.