- 中文名稱
Perifosine (50 mg)
- 英文名字
- Perifosine, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium, inner salt
- 供應(yīng)商
- Cayman
- 產(chǎn)品貨號(hào)
- 10008112-50
- 產(chǎn)品報(bào)價(jià)
- ￥9142/50 mg
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購買方式
- 產(chǎn)品新聞
- 背景資料
- Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth -growth inhibition -GI50) = 5uM at 24h) and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.
- 產(chǎn)品描述
- An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth -growth inhibition -GI50) = 5 uM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
- 產(chǎn)品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說明書為準(zhǔn)。下單前，請(qǐng)瀏覽說明書確認(rèn)。
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