Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. It contributes about 17% of the total fatty acids esterified to phosphatidylcholine in porcine platelets. Oleic acid ethyl ester is a neutral, more lipid-soluble form of oleic acid. As the free acid, it inhibits collagen-stimulated platelet aggregation by approximately 90% at a concentration of 10 ug/ml. It inhibits fMLF-induced neutrophil aggregation and degranulation by 55% and 68%, respectively, at 5 uM. Oleic acid, whether applied extracellularly -EC50 = ~60 uM) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.
產(chǎn)品描述
Oleic acid ethyl ester is a neutral, more lipid-soluble form of oleic acid.