中文名稱(chēng)

9-Z),11-E),13-E)-Octadecatrienoic Acid ethyl ester (50 mg)

英文名字

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

10008350-50

產(chǎn)品報(bào)價(jià)

￥7840/50 mg

產(chǎn)品說(shuō)明書(shū)

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購(gòu)買(mǎi)方式

產(chǎn)品新聞

背景資料

9-Z),11-E),13-E)-Octadecatrienoic Acid ethyl ester -.alpha.-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. .alpha.-ESA is metabolized and converted to conjugated linoleic acid -9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, .alpha.-ESA induced apoptosis through up-regulation of GADD45, p53, and PPAR.gamma.. In DLD-1 cells supplemented with .alpha.-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 uM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 uM for different isoforms of the enzymes. .alpha.-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

產(chǎn)品描述

.alpha.-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

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