PtdIns--3,5)-P2 -1,2-dihexanoyl) -sodium salt) is a synthetic analog of natural PtdIns featuring saturated C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as that of the natural compound. PtdIns--3,5)-P2 is rapidly synthesized from PtdIns--3)-P1 in yeast when a PtdIns--3)-P5-OH kinase is activated during hyperosmotic conditions. PtdIns--3,5)-P2 is also present in mammalian cells, such as monkey COS-7 cells, where a similar biosynthetic route has been demonstrated.
產(chǎn)品描述
An analog of naturally occuring PtdIns--3,4)-P2 that contains sulfur rather than oxugen at the sn-3 postion of the glycerol backbone; potential PLC-mediated hydrolysis yields a free thiol which could then react with chromogenic reagents such as Ellman s reagent