D-myo-Inositol-1,4,5-triphosphate -Ins-1,4,5)P3) is a key second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins-1,4,5)P3 to one of several Ins-1,4,5)P3 receptors results in opening of the calcium channels and an increase in intracellular calcium. Ins-4,5)P2 is a metabolite of Ins-1,4,5)P3 that lacks a phosphate at the 1 position. Ins-4,5)P2 formation has been reported as an intermediate in the metabolism Ins-1,4,5)P3 in GH3 pituitary cells.
產(chǎn)品描述
Ins-4,5)P2 is a metabolite of Ins-1,4,5)P3 that lacks a phosphate at the 1 position. Ins-4,5)P2 formation has been reported as an intermediate in the metabolism Ins-1,4,5)P3 in GH3 pituitary cells.{14532}