Bimatoprost -free acid) is a metabolically stable analog of prostaglandin F2.alpha. -PGF2.alpha.) and a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2.alpha.. At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2.alpha. binding with a Ki of 1.1 nM. The isopropyl ester of bimatoprost is slightly better than PGF2.alpha. isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation. 8-iso-17-phenyl PGF2.beta. is an isomer of bimatoprost that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2.beta..
產(chǎn)品描述
8-iso-17-phenyl PGF2.beta. is an isomer of bimatoprost -free acid) that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2.beta..