Ins-1,2)P2 -sodium salt) is one of the many inositol phosphate -InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP Ins-1,4,5)P3, is a second messenger produced in cells by phospholipase C -PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins-1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins-1,2)P2 -tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins-1,4,5)P3 at initiating Ca2+ release when injected into Xenopus oocytes.
產(chǎn)品描述
A member of the InsP family of small, soluble second messengers