中文名稱

G-1 (50 mg)

英文名字

G-1, rel-1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3aR,4S,5,9bS-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone

供應(yīng)商

Cayman

產(chǎn)品貨號

10008933-50

產(chǎn)品報(bào)價(jià)

￥8330/50 mg

產(chǎn)品說明書

點(diǎn)擊查看

購買方式

產(chǎn)品新聞

背景資料

GPR30 is a transmembrane G protein-coupled receptor -GPCR) localized to endoplasmic reticulum -ER) that binds estradiol with high affinity, activating multiple intracellular signaling pathways. G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM. Competitive binding studies in ER.alpha.- and ER.beta.-expressing cells yielded Ki values for estradiol of 0.30 and 0.38 nM, respectively, with no substantial binding of G-1 at 1 uM. The discovery of G-1, a compound that does not bind classical ERs, should facilitate further physiological experiments to define the role of GPR30 in vivo.

產(chǎn)品描述

G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM. Competitive binding studies in endoplasmic reticulum .alpha.- -ER.alpha.-) and ER.beta.-expressing cells yielded Ki values for estradiol of 0.30 and 0.38 nM, respectively, with no substantial binding of G-1 at 1 uM.{14210} The discovery of G-1, a compound that does not bind classical ERs, should facilitate further physiological experiments to define the role of GPR30 in vivo.

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

分享到：