.beta.-Gal-NONOate is a nitric oxide -NO) donor which releases NO following activation by .beta.-galactosidase. .beta.-Gal-NONOate is stabile in aqueous solution at neutral and acidic pH for several hours, exhibits good water solubility, and is able to cross the cell membrane. Following enzymatic hydrolysis, .beta.-Gal-NONOate decomposes with a half-life of six minutes at pH 5.6. .beta.-Gal-NONOate is cytotoxic to a number of cancer cell-lines and exhibits high bactericidal activity against E. coli transformed with the .beta.-galactosidase gene.
產(chǎn)品描述
.beta.-Gal-NONOate is a nitric oxide -NO) donor which releases NO following activation by .beta.-galactosidase.{9700} .beta.-Gal-NONOate is stabile in aqueous solution at neutral and acidic pH for several hours, exhibits good water solubility, and is able to cross the cell membrane. Following enzymatic hydrolysis, .beta.-Gal-NONOate decomposes with a half-life of six minutes at pH 5.6.{9700} .beta.-Gal-NONOate is cytotoxic to a number of cancer cell-lines and exhibits high bactericidal activity against E. coli transformed with the .beta.-galactosidase gene.{9700,14266}