中文名稱

D-myo-Inositol-1,3,4,5,6-pentaphosphate -ammonium salt) (5 mg)

英文名字

Ins(1,3,4,5,6)P5|1,3,4,5,6-IP5 (sodium salt), D-myo-Inositol-1,3,4,5,6-pentaphosphate -ammonium salt), D-myo-inositol-1,3,4,5,6-penta(hydrogen phosphate), decaammonium salt

供應商

Cayman

產(chǎn)品貨號

10009851-5

產(chǎn)品報價

￥24010/5 mg

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

Inositol-1,3,4,5,6-pentaphosphate -Ins-1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It can be interconverted with Ins-3,4,5,6)P4 by a 1-kinase/1-phosphatase cycle, as well as with Ins-1,4,5,6)P4 in a 3-kinase/3-phosphatase cycle. Ins-1,3,4,5,6)P5 inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. It exhibits antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Ins-1,3,4,5,6)P5 binds to the PH domain of Grp1 with a Kd of 590 nM.

產(chǎn)品描述

A member of the inositol phosphate -InsP) family of small, soluble second messengers; inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells; exhibits antiangiogenic activity as well as antitumor effects; binds to the PH domain of Grp1 with a Kd of 590 nM.

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準確的產(chǎn)品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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