中文名稱

CAY10526 (50 mg)

英文名字

CAY10526, 4-(benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one

供應(yīng)商

Cayman

產(chǎn)品貨號

10010088-50

產(chǎn)品報價

￥21070/50 mg

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

Prostaglandin E2 -PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 -COX-2) and microsomal PGE synthase-1 -mPGES-1). CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 uM without any effect on COX-2 expression.

產(chǎn)品描述

An inhibitor of mPGES-1 expression; inhibits PGE2 production in LPS-stimulated RAW 264.7 cells -IC50 = 1.8 uM) without affecting COX-2 expression

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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