中文名稱

Lovastatin (25 mg)

英文名字

Lovastatin, 2-methyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid

供應(yīng)商

Cayman

產(chǎn)品貨號

10010338-25

產(chǎn)品報價

￥1008/25 mg

產(chǎn)品說明書

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背景資料

Hydroxymethylglutaryl-coenzyme A -HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering drugs. Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from Aspergillus terreus. Marketed as MevinolinTM, MevacorTM, and under several other trade names, Lovastatin was the first HMG-CoA reductase inhibitor to be used in the treatment of hypercholesterolemia. It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.6 nM for the open ring, hydroxy acid form of the molecule. During a three week study in dogs, a dose of 8 mg/kg per day resulted in a 29% reduction in plasma cholesterol. Lovastatin also suppresses TNF-induced NF-.kappa.B activation -IC50 ~ 15 uM), which potentiates apoptosis in human myeloid leukemia cells and thus, maybe useful in treating cancer.

產(chǎn)品描述

A potent, competitive inhibitor of HMG-CoA reductase -Ki = 0.6 nM)

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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